SURUNKALI NAZOFARENGIAL INFEKSIYA O'CHOQLARINING REVMATIK ISITMANI PATOGENEZI VA KECHISHIDAGI TA'SIRI
Abstract
Revmatik isitmani rivojlanishining etiologik omili nazofarengial infektsiyasini
keltirib chiqaradigan A guruhi beta-gemolitik streptokokk hisoblanadi [5,7, 10, 11, 15].
Revmatik yurak kasalliklarining patogenetik tushunchalari AGBGS va inson
oqsillari o'rtasidagi o'zaro ta'sirga asoslangan streptokokk antigenlariga g'ayritabiiy
immun javob nazariyasiga asoslanadi. So'nggi paytlarda ushbu nazariya streptokokk
M-oqsil molekulasi va tropomiozinning homologiyasi , M-5 pexin fragmenti va
sarkolemma, M3, M5 , M18 serotiplarining 3 epigoniga antitanachalarning yurak
to'qimalari bilan reaksiyaga kirishish qobiliyati haqidagi bir qator yangi dalillar olindi
[1]. Olingan ma'lumotlar revmatik yurak kasalliklarida streptokokk infektsiyasining
ta'sirining asosiy patogenetik mexanizmi sifatida molekulyar mimikriya tushunchasini
tasdiqladi: streptokokk antigenlariga javoban hosil bo'lgan antitanachalar
organizmning autoantigenlari bilan o'zaro ta'sir qiladi [8].
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