THE ROLE OF CANCER CELL LINES IN MODERN ONCOLOGY RESEARCH
Keywords:
Keywords: Cancer, cell lines, A375, A431, A498, A549, A2780, B16-F1, BE(2)-C, BT-20, BxPC-3 (BxPC3), Caco-2 [Caco2]Abstract
Abstract: Cancer cell lines are pivotal tools in cancer research, providing
invaluable insights into tumor biology, drug development, and treatment response.
Derived from human tumors, these immortalized cell lines allow for the study of cancer
mechanisms in a controlled laboratory environment. This article reviews the
characteristics, types, and applications of various cancer cell lines, including their role
in screening potential therapeutic agents and understanding cancer cell behavior. While
they offer significant advantages in research, including reproducibility and ease of
manipulation, limitations such as genetic drift and a lack of tumor microenvironment
simulation must be acknowledged. This review underscores the importance of cancer
cell lines in advancing cancer research and highlights the need for complementary
approaches to fully understand the complexities of cancer.
References
References:
Puzyn T., Rasulev B., Gajewicz A., Hu X., Dasari T.P., Michalkova A., Hwang
H.M., Toropov A., Leszczynska D., Leszczynski J. Using Nano-QSAR to predict the cytotoxicity of metal oxide nanoparticles, Nature Nanotechnology, 2011, 6,
-178
Turabekova, M.A., Rasulev, B., Dzhakhangirov, F.N., Leszczynska, D.,
Leszczynski, J., Aconitum and Delphinium alkaloids of curare-like activity. QSAR
analysis and molecular docking of alkaloids into AChBP, European Journal of
Medicinal Chemistry, 2010, 45 (9), 3885-3894
Gajewicz A., Rasulev B., Dinadayalane T., Urbaszek P., Puzyn T., Leszczynska D.,
Leszczynski J. Advancing risk assessment of engineered nanomaterials:
Application of computational approaches, Advanced Drug Delivery Reviews, 2012,
(15), 1663-1693
Patnode K., Demchuk Z., Johnson S., Voronov A., Rasulev B. Combined
Computational Protein-ligand Docking and Experimental Study of Bioplastic Films
from Soybean Protein, Zein and Natural Modifiers, ACS Sustainable Chemistry and
Engineering, 2021, 9, 10740-10748,
Abdulrahman, H.L., Uzairu, A. & Uba, S. QSAR, Ligand Based Design and
Pharmacokinetic Studies of Parviflorons Derivatives as Anti-Breast Cancer Drug
Compounds Against MCF-7 Cell Line. Chemistry Africa, 2021, 4, 175–187.
doi.org/10.1007/s42250-020-00207-7
Bohari, M. H., Srivastava, H. K., & Sastry, G. N. Analogue-based approaches in
anti-cancer compound modelling: the relevance of QSAR models. Organic and
Medicinal Chemistry Letters, 2011, 1(1), 3. doi.org/10.1186/2191-2858-1-3
Xu-Yan Wang, Chuang-Jun Li, Jie Ma, Chuan Li, Fang-You Chen, Nan Wang,
Cang-Jie Shen, Dong-Ming Zhang. Cytotoxic 9,19-cycloartane type triterpenoid
glycosides from the roots of Actaea Dahurica. Phytochemistry, 2019, 160, 48-55,
doi.org/10.1016/j.phytochem.2019.01.004.
