THE ROLE OF CANCER CELL LINES IN MODERN ONCOLOGY RESEARCH
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Keywords: Cancer, cell lines, A375, A431, A498, A549, A2780, B16-F1, BE(2)-C, BT-20, BxPC-3 (BxPC3), Caco-2 [Caco2]##article.abstract##
Abstract: Cancer cell lines are pivotal tools in cancer research, providing
invaluable insights into tumor biology, drug development, and treatment response.
Derived from human tumors, these immortalized cell lines allow for the study of cancer
mechanisms in a controlled laboratory environment. This article reviews the
characteristics, types, and applications of various cancer cell lines, including their role
in screening potential therapeutic agents and understanding cancer cell behavior. While
they offer significant advantages in research, including reproducibility and ease of
manipulation, limitations such as genetic drift and a lack of tumor microenvironment
simulation must be acknowledged. This review underscores the importance of cancer
cell lines in advancing cancer research and highlights the need for complementary
approaches to fully understand the complexities of cancer.
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